In the present patient population, leg pain was reportedly much more serious than LBP (Fig. 11). Tramadol/acetaminophen relieved leg pain within 7 days, while LBP was unchanged until many weeks later. In this study, radiculopathy could possibly be related to spinal lesions
Tramadol is known as substantially excreted by the kidney, along with the chance of negative effects to this drug may be greater in patients with impaired renal function. Because elderly patients may have decreased renal function, care should be drawn in dose selection, also it may be beneficial to monitor renal function.